This easy turkey tetrazzini is a creamy and cheesy comfort food classic, perfect for using up leftover turkey. With tender spaghetti coated in a rich sauce made from cream of mushroom soup, sour cream, and chicken broth, this dish is loaded with flavor. Topped with freshly grated parmesan and melty mozzarella, it’s baked to golden perfection for a crowd-pleasing dinner.

Ingredients

12 ounces spaghetti (uncooked)
2 cans (10.5 ounces each) condensed cream of mushroom soup (see note)
1 cup sour cream
1 cup chicken broth
1/2 teaspoon onion powder
1/2 teaspoon garlic powder
Pepper (to taste)
2 cups cooked turkey (shredded or chopped)
1 cup freshly grated parmesan cheese
2 cups shredded mozzarella cheese

Instructions

Preheat the Oven: Set your oven to 375°F and position the rack in the top third.
Cook the Spaghetti: Boil a large pot of salted water and cook the spaghetti 2 minutes less than the package instructions suggest.
Prepare the Sauce: In a medium bowl, mix the cream of mushroom soup, sour cream, chicken broth, onion powder, garlic powder, and pepper. Stir in the cooked turkey until combined.
Assemble the Dish: Drain the spaghetti and place it in a 9×13-inch casserole dish. Pour the turkey and sauce mixture over the pasta, toss until evenly coated, and spread it in an even layer.
Add Cheese and Bake: Top with parmesan and mozzarella cheese. Bake, uncovered, for 20 minutes or until hot and bubbly.
Optional Broil: For a golden-brown finish, broil the dish for a few minutes. Watch carefully to prevent burning. Serve immediately and enjoy this hearty, satisfying meal.

Why You’ll Love This Recipe

Effortless Preparation: Perfect for busy nights, it comes together quickly with simple ingredients.
Versatile: Ideal for using leftover turkey, chicken, or even ham.
Family Favorite: The cheesy, creamy texture is sure to win everyone over.

Tips

Perfect Pasta: Slightly undercook the pasta to prevent it from becoming mushy in the oven.
Cheese Choices: For extra flavor, try adding some sharp cheddar or gruyere.
Leftover Upgrade: This recipe is an excellent way to repurpose Thanksgiving or holiday turkey.

Variations and Substitutions

Protein Options: Swap turkey with cooked chicken or ham.
Vegetarian Alternative: Replace the meat with sautéed mushrooms or a mix of your favorite veggies.
Gluten-Free: Use gluten-free pasta and a gluten-free mushroom soup.

FAQs

Can I prepare this ahead of time?
Yes! Assemble the casserole, cover it, and store it in the refrigerator for up to 24 hours. Bake it fresh before serving.

What can I substitute for cream of mushroom soup?
Make a homemade version using a roux, chicken broth, and sautéed mushrooms for added flavor.

Serving and Suggestions

Serve this turkey tetrazzini with a fresh green salad or steamed vegetables for a complete meal. Pair it with a crusty baguette or garlic bread to soak up the creamy sauce. Leftovers reheat beautifully for lunch or dinner the next day!